Institute of Biomedical Research and InnovationRegenerative Medicine Research

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R&D of novel therapy for regeneration of brain function

It had been believed that neuronal regeneration cannot occur after injury. The major causes of bed-ridden are stroke and dementia, and there is no effective therapy for regeneration of brain function at present.

We have demonstrated that the neuronal regeneration can be achieved by therapeutic angiogenesis using hematopoietic stem cell. Our clinical trial of autologous hematopoietic stem cell transplantation for stroke patients showed favorable trends in acceleration of functional recovery. Furthermore, we have recently figured out the mechanism of how hematopoietic stem cell activates angiogenesis at ischemic tissue. Based on these findings, R&D projects of novel therapy for stroke and dementia are ongoing.

田口 明彦

ProfessorAkihiko Taguchi

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