Institute of Biomedical Research and InnovationDepartment of Brain and Neurodegenerative Disease Research

The study protocol newly created by our research group was published in the American academic journal STAR Protocols. (Sasahara T., and Hoshi M., High-throughput screening for agonists of ROS production in live human vascular endothelial cells. Star Protoc., 3(1):101053. doi: 10.1016/j.xpro.2021.101053)

Our research group’s research results were published in iScience, the American academic journal. (Sasahara T., Satomura K., Tada M., Kakita A., and Hoshi M., Alzheimer’s Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells. iScience, 24(9):102936. doi: 10.1016/j.isci.2021.102936)

A research review written by Prof. M. Hoshi was published in the American academic journal, British Journal of Pharmacology. This research review was highly evaluated and was featured on the cover page. (Hoshi M., Multi-angle development of therapeutic methods for Alzheimer’s disease. Br. J. Pharmacol., 178(4):770-783. doi: 10.1111/bph.15174)

The research results of our research group were published in the American academic journal, Journal of Comparative Neurology. (Murata K., Kinoshita T., Ishikawa T., Kuroda K., Hoshi M., and Fukazawa Y., Region- and neuronal-subtype-specific expression of Na,K-ATPase alpha and beta subunit isoforms in the mouse brain. J. Comp. Neurol., 528(16):2654-2678. doi: 10.1002/cne.24924)

The research results of our research group were published in the American academic journal, Journal of Biological Chemistry. (Xiao Y., Matsuda I., Inoue M., Sasahara T., Hoshi M., and Ishii Y., NMR-based site-resolved profiling of β-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril. J. Biol. Chem., 295(2):458-467. doi: 10.1074/jbc.RA119.008522)

A research review written by Prof. M. Hoshi was published in the Dutch academic journal, Progress in Molecular Biology and Translational Science. (Hoshi M., Tracking down a missing trigger for Alzheimer’s disease by mass spectrometric imaging based on brain network analysis. Prog. Mol. Biol. Transl. Sci., 168:25-55. doi: 10.1016/bs.pmbts.2019.05.011)

Our research group’s research results were published in iScience, the American academic journal. (Komura H., Kakio S., Sasahara T., Arai Y., Takino N., Sato M., Satomura K., Ohnishi T., Nabeshima Y.I., Muramatsu S.I., Kii I., and Hoshi M.., Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion. iScience, 13:452-477. doi: 10.1016/j.isci.2019.01.018)