Institute of Biomedical Research and InnovationDepartment of Brain and Neurodegenerative Disease Research

Publications

Articles

  1. Sasahara, T., and *Hoshi, M. High-throughput screening for agonists of ROS production in mitochondria or plasma membrane of live human vascular endothelial cells STAR Protoc. (2022) 21;3(1): 101053.
    doi: 10.1016/j.xpro.2021.101053. (IF=1.344, CI=1)
  2. Sasahara, T., Satomura, K., Tada, M., Kakita, A., and *Hoshi, M. Alzheimer’s Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cell., iScience (2021) 24, 102936. Doi: 10.1016/j.isci.2021.102936 (IF= 6.107, CI= 7)
  3. Hoshi, M., Multi-angle development of therapeutic methods for Alzheimer's disease., Br. J. Pharmacol. (Cover) (2021) Feb;178(4):770-783. doi: 10.1111/bph.15174. (IF= 9.473, CI= 6)
  4. Iwaya, N., Goda, N., Matsuzaki, M., Narita, A., Shigemitsu, Y., Tenno, T., Abe, Y., Hoshi, M., and Hiroaki,H., Principal Component Analysis of Data from NMR Titration Experiment of Uniformly 15N Labelled Amyloid beta (1–42) Peptide with Osmolytes and Phenolic Compounds, Arch. Biochem. Biophys. (2020) 690:108446, doi:10.1016/j.abb.2020.108446 (IF= 4.114, CI= 6)
  5. *Murata, K., Kinoshita,T., Ishikawa, T., Kuroda, K., Hoshi, M., and *Fukazawa, Y., Region- and neuronal- subtype-specific expression of Na, K-ATPase alpha and beta subunit isoforms in the mouse brain J. Comp. Neurol. (2020) 528, 2654-2678. doi: 10.1002/cne.24924 (IF= 3.028, CI= 25）
  6. Xiao, Y., Matsuda, I., Inoue, M., Sasahara, T., Hoshi, M., and *Ishii, Y. NMR-based site-resolved profiling of β-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril. J. Biol. Chem. (2020) 295, 458-467. doi: 10.1074/jbc.RA119.008522 (IF= 5.485, CI= 16)
  7. Komura, H., Kakio, S., Sasahara, T., Arai, Y., Takino, N., Sato, M., Satomura, K., Ohnishi, T., Nabeshima, Y., Muramatsu, S., Kii, I., and *Hoshi, M. Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion iScience (2019) 13: 452-477.
    https://doi.org/10.1016/j.isci.2019.01.018 (IF= 6.107, CI= 12）
  8. Xiao, YL., McElheny, D., Hoshi, M., Ishii, Y., Solid-State NMR Studies of Amyloid Materials: A Protocol to Define an Atomic Model of Aβ (1-42) in Amyloid Fibrils, Methods Mol. Biol. (2018) 1777, 407-428. doi: 10.1007/978-1-4939-7811-3_26. (IF=0.368, CI= 1)
  9. Shigemitsu, Y., Iwaya, N., Goda, N., Matsuzaki, M., Tenno, T., Narita, A., Hoshi, M.,
    *Hiroaki, H. Nuclear magnetic resonance evidence for the dimer formation of beta amyloid peptide 1-42 in 1,1,1,3,3,3-hexafluoro-2-propanol Anal. Biochem. (2016) 498, 59-67（IF= 3.191, CI= 15）
  10. Ohnishi, T., Yanazawa, M., Sasahara, T., Kitamura, Y., Hiroaki,H., Fukazawa, Y., Kii, I., Nishiyama, T., Kakita, A., Takeda, H., Takeuchi, A., Arai, Y., Ito, A., Komura, H., Hirao, H., Satomura, K., Inoue, M., Muramatsu, S., Matsui,K., Tada, M., Sato, M., Saijyo, E., Shigemitsu,Y., Sakai,S., Umetsu, Y., Goda,N., Takino,N., Takahashi, H., Hagiwara, M., Sawasaki, T., Iwasaki, G.,　Nakamura, Y., Nabeshima, Y., Teplow, D.B., and *Hoshi, M. Na,K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly Proc. Natl. Acad. Sci. USA. (2015) 112, E4465-E4474 (IF=12.779, CI=132)
  11. Parthasarathy, S., Inoue, M., Xiao, Y., Matsumura, Y., Nabeshima, Y., Long, F., Hoshi, M., and *Ishii, Y. Structural Insight into an Alzheimer’s Brain-Derived Spherical Assembly of Amyloidβ by Solid-state NMR J. Amer. Chem. Soc. (2015) 137, 6480-6483 (IF= 16.383, CI=59)
  12. Xiao, Y., Ma. B., McElheny, D., Parthasarathy, S., Long, F., Hoshi, M., Nussinov, R., and * Ishii, Y. Aβ（1-42）fibril structure illuminates self-recognition and replication of amyloid in Alzheimer’s disease Nature Str. Mol. Biol. (2015) 22, 499-505 doi: 10.1038/nsmb.2991. Epub 2015 May 4. (IF= 18.361 CI=747)
  13. *Sato, K., Maeda, T., and Hoshi, M. Asn27 is Essential for the Neurotoxicity of Amyloid β(1-42) Peptide Int. J. Peptide Res. Therapeutics (2012) 18, 341-345 (IF=2.191, CI=0)
  14. *Hiroaki, H., Umetsu, Y., Nabeshima, Y., Hoshi, M., Kohda, D. A Simplified Recipe For Assigning Amide NMR Signals Using Combinatorial 14N Amino Acid Inverse-Labeling J. Struct. Funct. Genomics (2011) 12, 167-174 (IF=5.723 , CI=24)
  15. Matsumura, S., Shinoda, K., Yamada, M., Yokojima, S., Inoue, M., Ohnishi, T., Shimada, T., Kikuchi, K., Masui, D., Hashimoto, S., Sato, M., Ito, A., Akioka, M., Takagi, S., Nakamura, Y., Nemoto, K., Hasegawa, Y., Takamoto, H., Inoue, H., Nakamura, S., Nabeshima, Y., Teplow, D.B., Kinjo, M., and *Hoshi, M. Two distinct amyloid β-protein (Aβ) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology and toxicity analyses J. Biol. Chem. (2011) 286, 11555-11562 (IF=5.485, CI= 129)
  16. Noguchi, A., Matsumura, S., Dezawa, M., Tada, M., Yanazawa, M., Ito, A., Akioka, M., Kikuchi, S., Sato, M., Ideno, S., Noda, M., Fukunari, A., Muramatsu, S., Itokazu, Y., Sato, K., Takahashi, H., Teplow, D.B., Nabeshima, Y., Kakita, A., Imahori, K., and *Hoshi, M. Isolation and characterization of patient-derived, toxic, high-mass amyloid β-protein (Aβ) assembly from Alzhiemer’s disease brains J. Biol. Chem. (2009) 284, 32895-32905 (IF=5.485, CI= 216)
  17. Roychaudhuri, R., Yang, M., Hoshi, M., and *Teplow, D.B. Amyloid β-protein assembly and Alzheimer disease J. Biol. Chem. (2009) 284, 4749-4753 (IF= 5.485, CI= 757)
  18. *Hoshi, M., Sato, M., Matsumoto, S, Noguchi, A., Yasutake, K., Yoshida, N., and Sato, K. Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β Proc. Natl. Acad. Sci. USA. (2003) 100, 6370-6375 (IF= 12.779, CI= 601)

English books

Hoshi, M. Tracking down a missing trigger for Alzheimer’s disease by mass spectrometric imaging based on brain network analysis, Ch.7 of Molecular Biology of Neurodegenerative Diseases: Visions for the Future: PMBTS Volume 168: AID 00439 (Teplow, D.B & Wolfe, M. Eds.) Elsevier (2019), 22-55.

Patents

  1. Hoshi, M., Sato, K. METHOD OF PREPARING AMYLOID BETA PROTEIN HAVING HIGH TOXICITY; Japan Patent Application (Publication No.JP 2001-247600 A)
  2. Hoshi, M. DRUG HAVING NEUROYTE DEATH CONTRASTIMULUS AND METHOD FOR SCREENING THE SAME; Japan Patent Application (Publication No.JP 2001-255318 A)
  3. Hoshi, M., Sato, M., Sato, K. SELF-ASSOCIATION TYPE AMYLOID β PROTEIN; Japan Patent Application (Publication No.JP 2002-105099 A)
  4. Hoshi, M. AGENT FOR PREVENTION AND TREATMENT OF DISEASE CAUSED BY AMYLOSPHEROID; Japan Patent Application (Publication No.JP 2006-342108 A)
  5. Hoshi, M., Naito, K., Ideno, S. ANTIBODY AND USE THEREOF; PCT Application (Publication No. WO 2006/016644) [Registered Patent] US Patent No. US 8168188 B1
  6. Hoshi, M. HUMAN AMYLOSPHEROID-LIKE ASSOCIATED PRODUCT; Japan Patent Application (Publication No.JP 2008-291025 A)
  7. Hoshi, M., Sato, M., Ideno, S., Naito, K.,Horie, S., Noda, M., Horii, H. ANTIBODY AND USE THEREOF; PCT Application (Publication No. WO2009/057664) [Registered Patent] Japan Patent Nos. 5185946 B2, 6128535 B2, US Patent No. US 8445649 B2, EP Patent No. EP 2224000 B1 (DE, GB, FR, CH/LI, BE)
  8. Hoshi, M. METHOD FOR PRODUCING SYNTHETIC AMYLOSPHEROID; PCT Application (Publication No. WO2013/094614)
  9. Hoshi, M. TARGET MOLECULE TO WHICH AMYLOSPHEROID BINDS AND INDUCES MATURE NEURONAL CELL DEATH, METHOD AND SUBSTANCE FOR INHIBITING AMYLOSPHEROID-INDUCED NEURONAL CELL DEATH, AND USES FOR SAID TARGET MOLECULE, METHOD, AND SUBSTANCE; PCT Application (Publication No. WO2013/099806) [Registered Patent] Japan Patent Nos. 5828461 B2, 6241855 B2, US Patent No. US 9751912 B2
  10. Hoshi, M., Arai, Y. AMYLOSPHEROID (ASPD)-LIKE STRUCTURE AND PHARMACEUTICAL COMPOSITION; PCT Application (Publication No. WO2017/179646) [Registered Patent] Japan Patent No. 7161401
  11. Hoshi, M., Sasahara, T., Saijo, E., Iwasaki, G., Mori, I. PEPTIDE FOR INHIBITING BINDING OF AMYLOSPHEROIDS (ASPD), AND EVALUATION AND SCREENING METHOD; PCT Application (Publication No. WO2017/179647)
  12. Hoshi, M., Arai, Y., Matida, K. CROSSLINKED PRODUCT OF AMYLOID-β PROTEIN (Aβ) ABLE TO BE SUBSTITUTE FOR AMYLOSPHEROID (ASPD), AND ANALYSIS OF ASPD; PCT Application (Publication No. WO2021/100744) [Registered Patent] Japan Patent No. 7383043 B2

*Registration information shows only those whose patent rights are still in force.

(As of March 7, 2024)

Publications

Articles English books Patents