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Overview

With our unique Blockmer-based oligonucleotide synthesis technology, we offer extremely high purity oligonucleotides in mg to ton scale at reasonable prices.
・Oligonucleotide Synthesis Service
・Blockmer™ intermediates Sales
・Joint development of equipments and synthetic technologies related to oligonucleotide production

Technology
Blockmer™ can significantly shorten process for oligonucleotide synthesis compared to the synthesis with monomer, which is conventional raw materials
・Blockmer™ makes it possible to reduce shortmer impurities andafter purification to obtain extremerly high-quality oligonucleotide (reducing shortmer impurities), which is unavoidable in conventional synthetic methods using monomers.
・The use of Blockmer™ can skip the difficult sequences in solid-phase synthesis, such as poly G sequences, by using ready-made poly G Blockmer™.
・By using Blockmer™, the manufacturing steps (controlled processes in GMP enveroment) can be shortened.
・In turn, the burden of document control related to GMP manufacturing can be reduced.
・The stereo-controlled Blockmer™ makes it possible to produce diastereomers (originated from chirality on the phosphorus atom) in a single state. In conventional solid-phase synthesis, the diastereomers are produced as a mixture.
・The loss of nucleosides used for synthesis can be reduced to a fraction of the conventional solid-phase synthesis method using monomers.
・The Production cost can be dramatically reduced, especially when compared to the use of expensive modified nucleotides

Establishment
October 2, 2015
Location
Kobe international business center 3F 5-5-2 Minatojima-Minamimachi, Chu-ku, Kobe-shi, Hyogo 650-0047 Japan
Branch Office
Kobe international business center 2F 5-5-2 Minatojima-Minamimachi, Chu-ku, Kobe-shi, Hyogo 650-0047 Japan
Medical Device Development center 3F 7-1-6 Minatojima-Minamimachi, Chu-ku, Kobe-shi, Hyogo 650-0047 Japan
Industry
Oligonucleotide Synthesis
Funding Round
Series B2
Raising
$5〜10M

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